Research ranges from studies on fundamental aspects of nuclear structure, yeast and mammalian genetics, and chromatin and DNA repair, to the biochemistry of disease states. Mechanisms of tumour growth/apoptosis, invasiveness, metastasis and chemotherapy resistance are studied. Research efforts are also directed toward understanding the biochemical mechanisms underlying obesity, diabetes, and heart disease, as well as the role of chronic inflammation in cancer and metabolic disease.
Specific areas of research
| Researcher |
Research topics |
|---|
| Dellaire, G. |
Nuclear structure and cancer biology; modelling cancer in zebrafish; chromatin and DNA repair; mechanisms of chemotherapy resistance |
| Dobson, M. J. |
Yeast and mammalian molecular genetics |
| Duncan, R. |
Membrane protein structure-function and cell-cell fusion |
| Kienesberger, P. C. |
Understanding molecular mechanisms of metabolic disorders; role of lipid metabolism and signalling in the development of obesity and diabetes-related comorbidities |
| Marignani, P. A. |
Tumour suppressors; cancer metabolism; signal transduction; animal models of human disease; drug discovery; whole genome manipulation; stem cell biology |
| McMaster, C. R. |
Genetics and chemical genetics to identify drug targets and drugs for unmet medical needs |
| Ro, H.-S. |
Role of chronic inflammation in cancer and metabolic diseases |
| Rosen, K. V. |
Cancer; cell death; cell signalling |
| Singer, R. A. |
Yeast chromatin; membrane dynamics |
| Too, C. K. L. |
Polypeptide and steroid hormone action; tumor growth/apoptosis |
| Waisman, D. M. |
Mechanisms of tumor growth; invasiveness and metastases |
