Research

 

Overview

The research areas explored at Dr. Barrett's lab include alcohol, tobacco, cannabis, brain imaging, human psychopharmacology, and other topics in the field of addictions research. Dr. Barrett’s research aims to elucidate how various pharmacological & non-pharmacological factors contribute to different addictive behaviours, as well as to determine the extent to which there are individual differences in these factors. The lab is comprised of a dynamic research team of professionals, graduate, and undergraduate students.

Publications

Spinella, T., Burdeyny, V., Oprea, A., Perrot, T., & Barrett, S. (2023). The impact of cannabidiol expectancy on cortisol responsivity in the context of acute stress: Associations with biological sex. Cannabis and Cannabinoid Research. 

DeGrace, S., Romero-Sanchiz, P., Yakovenko, I., Barrett, S., Tibbo, P., Cosman, T., Atasoy, P., & Stewart, S. (2023). Do we really need two sessions?: The use of a structured interview as a trauma cue reactivity paradigm. International Journal of Methods in Psychiatric Research, e1979. 

Mahu, I., Conrod, P., Barrett, S., Sako, A., Swansburg, J., & Stewart, S. (2023). The four-factor personality model and its qualitative correlates among opioid agonist therapy clients. Frontiers in Psychiatry, 14, 1129274. 

Shephard, A., Dolek, S., & Barrett, S. (2023). Investigating predictors of problematic alcohol, cannabis, and nicotine use among legal users of all three substances. Frontiers in Psychiatry, 14, 1110415. 

Spinella, T., Bartholomeusz, J., Stewart, S., & Barrett, S. (2023). Perceptions about THC and CBD effects among adults with and without prior cannabis experience. Addictive Behaviors, 137. 

Perry, R., Girgulis, J., Harrison, S., & Barrett, S. (2023). Dual users' perceptions of the addictive properties of cigarettes versus e-cigarettes. Addictive Behaviors, 136, 107483.

Romero-Sanchiz, P., Mahu, I., Barrett, S., Salmon, J., Al-Hamdani, M., Swansburg, J., & Stewart, S. (2022). Craving and emotional responses to trauma and cannabis cues in trauma-exposed cannabis users: Influence of PTSD symptom severity. Addictive Behaviors, 125, 107126.

Spinella, T., Stewart, S., Naugler, J., Yakovenko, I., & Barrett, S. (2021). Evaluating cannabidiol (CBD) expectancy effects on acute stress and anxiety in healthy adults: A randomized crossover study. Psychopharmacology, 238(7), 1965-1977.

Shephard, A., & Barrett, S. (2021). The impacts of caffeine administration, expectancies, and related stimuli on coffee craving, withdrawal, and self-administration. Journal of Psychopharmacology (Oxford), https://doi.org/10.1177/02698811211032447

Mahu, I., Barrett, S., Conrod, P., Bartel, S., & Stewart, S. (2021). Different drugs come with different motives: Examining motives for substance use among people who engage in polysubstance use undergoing methadone maintenance therapy (MMT). Drug and Alcohol Dependence, 109133.

Farrelly, K., Romero‐Sanchiz, P., Mahu, T., Barrett, S., Collins, P., Rasic, D., & Stewart, S. (2021). Posttraumatic stress disorder symptoms and coping motives are independently associated with cannabis craving elicited by trauma cues. Journal of Traumatic Stress, 2021-07-19.

Spinella, T., Barrett, S., & Schlagintweit, H. (2020). The relative impact of acute nicotine and tobacco administration on craving, withdrawal, and cigarette self-administration in dependent and nondependent smokers. Experimental and Clinical Psychopharmacology, Advance online publication

Spinella, T., Perry, R., Schlagintweit, H., & Barrett, S. (2020). The generalizability of clinical and experimental tobacco research: Do exclusion criteria impact men and women differently? Journal of Psychopharmacology (Oxford), 34(5), 584-585.

Spinella, T., Stewart, S., & Barrett, S. (2019). Context matters: Characteristics of solitary versus social cannabis use. Drug and Alcohol Review, 38(3), 316-320.

Perry, R.N., Schlagintweit, H.E., Darredeau, C., Helmick, C., Newman, A.J., Good, K.P., Barrett, S.P. (2019). The impacts of actual and perceived nicotine administration on insula functional connectivity with the anterior cingulate cortex and nucleus accumbens. Journal of Psychopharmacology

Mahu, I.T., Conrod, P.J., Barrett, S.P., ..., Stewart, S.H. (2019). Specificity of personality relationships to particular forms of concurrent substance use among methadone maintenance therapy clients. Addictive Behaviours, 98(106056)

Schlagintweit, H.E., Perry, R.N., Darredeau, C., Barrett, S.P. (2019). Non-pharmacological considerations in human research of nicotine and tobacco effects: A review. Nicotine & Tobacco Research, ntz064

Spinella, T.C., Stewart, S.H., Barrett, S.P. (2019). Context matters: Characteristics of solitary versus social cannabis use. Drug and Alcohol Review, 8(3).

Morriscey, C., Shephard, A., Van Houdt, A., Kerr, D., & Barrett, S. (2019). Using ‘smart’ technology to aid in cigarette smoking cessation: Examining an innovative way to monitor and improve quit attempt outcomes. Journal of Smoking Cessation, 14(3), 149-154.

Keough, M., O’Connor, R., Swansburg, J., Barrett, S., Hodgins, D., & Stewart, S. (2018). Joint effects of impulsive and self-regulatory process on gambling frequency. Journal of Gambling Issues, (38).

Gendy, M., Di Ciano, P., Kowalczyk, W., Barrett, S., George, T., Heishman, S., & Le Foll, B. (2018). Testing the PPAR hypothesis of tobacco use disorder in humans: A randomized trial of the impact of gemfibrozil (a partial PPARα agonist) in smokers. PloS One, 13(9), E0201512.

Shlagintweit, H.E., Campbell, N.K., Barrett, S.P. (2017). Quit Intentions Moderate Subjective and Physiological Responses to Acute Nicotine Replacement Therapy Administration in Dependent Smokers. Nicotine & Tobacco Research, 19(8)

Mahu, I. T., Barrett, S. P., Peters, L. R., Fulton, H. G., & Stewart, S. H. (2016). Personality traits and methadone dose and compliance independently predict concurrent substance use in clients undergoing methadone maintenance treatment for opiate addiction. Canadian Journal of Addiction, 7(4), 28.

Stewart, M. J., MacNevin, P. L. D., Hodgins, D. C., Barrett, S. P., Swansburg, J., & Stewart, S. H. (2016). Motivation-Matched Approach to the Treatment of Problem Gambling: A Case Series Pilot Study. Journal of Gambling Issues, 33, 124-147.

Schlagintweit, H. E., & Barrett, S. P. (2016). Does acute tobacco smoking prevent cue-induced craving?. Journal of Psychopharmacology, 30(5), 468-473.

Barrett, S. P., Jemcov, A., & Darredeau, C. (2016). Patterns and Effects of Alcohol and Psychostimulant Co-administration: a Brief Review of Pharmacological Considerations and Subjective Responses. Current Addiction Reports, 3(1), 138-143.

Reymarova, E., Schlagintweit, H. E., & Barrett, S. P. (2015). The impact of social context on cigarette self-administration in nondependent smokers. Behavioural pharmacology, 26(7-Special Issue Pharmacological Approaches To The Study Of Social Behaviour-Part 2: Social Modul), 627-630.

Balter, L. J., Good, K. P., & Barrett, S. P. (2015). Smoking cue reactivity in current smokers, former smokers and never smokers. Addictive behaviors, 45, 26-29.

Battista, S. R., MacKinnon, S. P., Sherry, S. B., Barrett, S. P., MacNevin, P. D., & Stewart, S. H. (2015). Does alcohol reduce social anxiety In DAILY life? A 22-DAY experience sampling study. Journal of Social and Clinical Psychology, 34(6), 508-528.

Barrett, S. P., Collins, P., & Stewart, S. H. (2015). The acute effects of tobacco smoking and alcohol consumption on video-lottery terminal gambling. Pharmacology Biochemistry and Behavior, 130, 34-39.

Good, K. P., Couture, M. E., Barrett, S., Schlagintweit, H., Tibbo, P. G., Stewart, S., & Milliken, H. (2015). Exposure to tobacco-related cues does not enhance cravings in patients with psychotic disorders relative to control smokers. Schizophrenia Bulletin, 41, 173-174. Oxford, Eng: Oxford University Press.

McGrath, D. S., Peloquin, M. P., Ferdinand, J. C., & Barrett, S. P. (2015). Acute effects of nicotine on alcohol cue-reactivity in nondependent and dependent smokers. Experimental and clinical psychopharmacology, 23(1), 29.

Schlagintweit, H. E., Greer, H., Good, K. P., & Barrett, S. P. (2015). The impact of anticipated and unanticipated smoking opportunities on cigarette smoking and nicotine lozenge responses. Drug and alcohol dependence, 147, 97-102.

Copp, S. R., Collins, J. L., Dar, R., & Barrett, S. P. (2015). The effects of nicotine stimulus and response expectancies on male and female smokers' responses to nicotine-free electronic cigarettes. Addictive behaviors, 40, 144-147.

Schlagintweit, H. E., Good, K. P., & Barrett, S. P. (2014). The impact of nicotine lozenges and stimulus expectancies on cigarette craving. Journal of Psychopharmacology, 28(8), 773-779.

Peloquin, M. P., McGrath, D. S., Telbis, D., & Barrett, S. P. (2014). Alcohol and tobacco cue effects on craving in non-daily smokers. Experimental and clinical psychopharmacology, 22(6), 502.

Kolajova, M., Fulton, H. G., Darredeau, C., & Barrett, S. P. (2014). Substance use patterns associated with injection drug use initiation in a low-threshold methadone-maintained sample. Journal of Substance Use, 19(6), 436-439.

McLarnon, M. E., Darredeau, C., Chan, J., & Barrett, S. P. (2014). Motives for the non-prescribed use of psychiatric medications: relationships with psychopathology, other substance use and patterns of use. Journal of Substance Use, 19(6), 421-428.

Dar, R., & Barrett, S. P. (2014). The effects of beliefs regarding drug assignment in experimental and field studies of nicotine delivery devices: A review. Journal of Psychopharmacology, 28(11), 1071-1079.

Stewart, M. J., Fulton, H. G., & Barrett, S. P. (2014). Powder and crack cocaine use among opioid users: is all cocaine the same?. Journal of addiction medicine, 8(4), 264-270.

Hecimovic, K., Barrett, S. P., Darredeau, C., & Stewart, S. H. (2014). Cannabis use motives and personality risk factors. Addictive behaviors, 39(3), 729-732.

Peloquin, M. P., Hecimovic, K., Sardinha, J., Stewart, S. H., & Barrett, S. P. (2013). The effect of snus on alcohol-related cigarette administration in dependent and non-dependent smokers. Pharmacology Biochemistry and Behavior, 114, 97-102.

Kolajova, M., Fulton, H. G., Darredeau, C., & Barrett, S. P. (2013). 357–Characteristics of earliest and most recent injection drug use in a Canadian low-threshold methadone maintenance treatment sample. European Psychiatry, 28, 1.

McLarnon, M. E., Darredeau, C., Chan, J., & Barrett, S. P. (2014). Motives for the non-prescribed use of psychiatric medications: relationships with psychopathology, other substance use and patterns of use. Journal of Substance Use, 19(6), 421-428.

Darredeau C., Stewart S. H., & Barrett S. P. (2013). The effects of nicotine content information on subjective and behavioural responses to nicotine-containing and denicotinized cigarettes. Behav Pharmacol.  Jun 19. (Electronic publication, ahead of print)

McGrath D.S., Dorbeck A., & Barrett S.P. (2013). The influence of acutely administered nicotine on cue-induced craving for gambling in at-risk video lottery terminal gamblers who smoke. Behavioral Pharmacology, 24(2):124-32. doi: 10.1097/FBP.0b013e32835f3cff.

Barrett, S. P., Campbell, M. L., Roach, S., Stewart, S. H., & Darredeau, C. (2013). The effects of alcohol on responses to nicotine‐containing and denicotinized cigarettes in dependent and nondaily smokers. Alcoholism: Clinical and Experimental Research, 37(8), 1402-1409.

Olthuis J. V., Darredeau C., & Barrett S. P. (2013). Substance use initiation: the role of simultaneous polysubstance use. Drug Alcohol Rev. 32(1):67-71. doi: 10.1111/j.1465-3362.2012.00470.x.

McLarnon M. E., Fulton H. G., MacIsaac C., & Barrett S. P. (2012). Characteristics of quetiapine misuse among clients of a community-based methadone maintenance program. Journal of Clinical Psychopharmacology, 32(5):721-3. doi: 10.1097/JCP.0b013e3182670648.

McGrath D. S., Barrett S. P., Stewart S. H., & McGrath P. R. (2012) A comparison of gambling behavior, problem gambling indices, and reasons for gambling among smokers and nonsmokers who gamble: evidence from a provincial gambling prevalence study. Nicotine and Tobacco Research, 14(7):833-9. doi: 10.1093/ntr/ntr294.

Barrett S. P., & Darredeau C. (2012). The acute effects of nicotine on the subjective and behavioural responses to denicotinized tobacco in dependent smokers. Behavioral Pharmacology, 23(3):221-7. doi: 10.1097/FBP.0b013e328353431c.

Campbell M. L., Bozec L. J., McGrath D., & Barrett S. P. (2012). Alcohol and tobacco co-use in nondaily smokers: an inevitable phenomenon? Drug Alcohol Review, 31(4):447-50. doi: 10.1111/j.1465-3362.2011.00328.x.

Fulton H. G., Barrett S. P., Stewart S. H., & Macisaac C. (2012). Prescription opioid misuse: characteristics of earliest and most recent memory of hydromorphone use. Journal of Addiction Medicine, (2):137-44. doi: 10.1097/ADM.0b013e3182351550.

McGrath D. S., Barrett S. P., Stewart S. H., & Schmid E. A. (2012). The effects of acute doses of nicotine on video lottery terminal gambling in daily smokers. Psychopharmacology, 220(1), 155-61. doi: 10.1007/s00213-011-2465-3.

McGrath D. S., Temporale K. L., Bozec L. J., & Barrett S. P. (2011). Polytobacco use in non-daily smokers: an issue requiring greater attention. Preventive Medicine, 53(4-5), 353-4. doi: 10.1016/j.ypmed.2011.08.004.

Barrett S. P. & Wagner E., (2011). A comparison between quick-release nicotine lozenges and Swedish-style snus for the acute management of craving. Tobacco Control, 20(5), 386. doi: 10.1136/tc.2011.043547.

Fulton H. G., Barrett S. P., Macisaac C., & Stewart S. H. (2011). The relationship between self-reported substance use and psychiatric symptoms in low-threshold methadone maintenance treatment clients. Harm Reduction Journal, 28(8), 18. doi: 10.1186/1477-7517-8-18.

McLarnon M. E., Monaghan T. L., Stewart S. H., & Barrett S. P. (2011). Drug misuse and diversion in adults prescribed anxiolytics and sedatives. Pharmacotherapy, 31(3), 262-72. doi: 10.1592/phco.31.3.262.

Barrett S. P., Campbell M. L., Temporale K., & Good K. B. (2011). The acute effect of Swedish-style snus on cigarette craving and self-administration in male and female smokers. Human Psychopharmacology, 26(1), 58-62.

Darredeau C., & Barrett S. P. (2010). The role of nicotine content information in smokers' subjective responses to nicotine and placebo inhalers. Human Psychopharmacology, 25(7-8), 577-81. doi: 10.1002/hup.1159.

Price S. R., Hilchey C. A., Darredeau C., Fulton H. G., & Barrett S. P. (2010) Energy drink co-administration is associated with increased reported alcohol ingestion. Drug Alcohol Review, 29(3), 331-3. doi: 10.1111/j.1465-3362.2009.00163.x.

Barrett S. P. (2010). The effects of nicotine, denicotinized tobacco, and nicotine-containing tobacco on cigarette craving, withdrawal, and self-administration in male and female smokers. Behavioral Pharmacology, 21(2), 144-52. doi: 10.1097/FBP.0b013e328337be68.

Price, S., Hilchey, C., Darredeau, C., Fulton, H., & Barrett, S. (2010). Energy drink co-administration is associated with increased reported alcohol ingestion. Drug and Alcohol Review, 29(3), 331-333.

McGrath, D., Stewart, S., Klein, R., & Barrett, S. (2010). Self-generated motives for gambling in two population-based samples of gamblers. International Gambling Studies, 10(2), 117-138.

McGrath D. S., & Barrett SP. (2009). The comorbidity of tobacco smoking and gambling: a review of the literature. Drug Alcohol Review, 28(6), 676-81. doi: 10.1111/j.1465-3362.2009.00097.x. Review.

Barrett S. P., Meisner J. R., & Stewart S. H. (2008). What constitutes prescription drug misuse? Problems and pitfalls of current conceptualizations. Current Drug Abuse Reviews, 1(3), 255-62. Review.

Meisner J. R., Darredeau C., McLarnon M. E., & Barrett S. P. (2008). Extended release stimulant medication misuse with alcohol co-administration. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 17(4), 181-2.

Fulton H. G., & Barrett S. P. (2008) A demonstration of intravenous nicotine self-administration in humans? Neuropsychopharmacology, 33(8), 2042-3; author reply 2044. doi: 10.1038/sj.npp.1301545.

Barrett S. P., Pihl R. O., Benkelfat C., Brunelle C., Young S. N., & Leyton M. (2008). The role of dopamine in alcohol self-administration in humans: individual differences. European Neuropsychopharmacology, 18(6), 439-47. doi: 10.1016/j.euroneuro.2008.01.008. Epub 2008 Mar 25.

Darredeau C., Barrett S. P., Jardin B., & Pihl R. O. (2007). Patterns and predictors of medication compliance, diversion, and misuse in adult prescribed methylphenidate users. Human Psychopharmacology, 22(8), 529-36.

Brunelle C., Barrett S. P., & Pihl R. O. (2007). Relationship between the cardiac response to acute intoxication and alcohol-induced subjective effects throughout the blood alcohol concentration curve. Human Psychopharmacology, 22(7), 437-43.

Barrett, S., Tichauer, M., Leyton, M., & Pihl, R. (2006). Nicotine increases alcohol self-administration in non-dependent male smokers. Drug and Alcohol Dependence, 81(2), 197-204.

McBride D., Barrett S. P., Kelly J. T., Aw A., & Dagher A. (2006). Effects of expectancy and abstinence on the neural response to smoking cues in cigarette smokers: an fMRI study. Neuropsychopharmacology, 31(12), 2728-38. Epub 2006 Apr 5.

Brunelle C., Barrett S. P., & Pihl R. O. (2006). Psychostimulant users are sensitive to the stimulant properties of alcohol as indexed by alcohol-induced cardiac reactivity. Psychology of Addictive Behaviors, 20(4), 478-83.

Barrett S. P., Darredeau C., & Pihl R. O. (2006). Patterns of simultaneous polysubstance use in drug using university students. Human Psychopharmacology, 21(4), 255-63.

Barrett S. P., Tichauer M., Leyton M., & Pihl R. O. (2006). Nicotine increases alcohol self-administration in non-dependent male smokers. Drug and Alcohol Dependence, 81(2), 197-204. Epub 2005 Jul 28.

Barrett S. P., Darredeau C., Bordy L. E., & Pihl R. O. (2005). Characteristics of methylphenidate misuse in a university student sample. Canadian Journal of Psychiatry, 50(8), 457-61.

Barrett S. P., Gross S. R., Garand I., & Pihl R. O. (2005). Patterns of simultaneous polysubstance use in Canadian rave attendees. Substance Use and Misuse, 40(9-10), 1525-37.

Barrett S. P., Boileau I., Okker J., Pihl R. O., & Dagher A. (2004). The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride. Synapse, 54(2), 65-71.

Barrett, S., Leyton, M. (2004). Acute phenylalanine/tyrosine depletion: A new method to study the role of catelcholamines in psychiatric disorders. Primary Psychiatry, 11(6), 37-41.

Brunelle C., Assaad J. M., Barrett S. P., AVila C., Conrod P. J., Tremblay R. E., & Pihl R. O. (2004). Heightened heart rate response to alcohol intoxication is associated with a reward-seeking personality profile. Alcohol: Clinical and Experimental Research, 28(3), 394-401.

Pihl, R., Barrett, S., Dagher, A., & Kelly, J. (2004). Level of abstinence mediates heart-rate response to cue-elicited craving in smokers. McGill Journal of Medicine, 8(1), 50.

Barrett S. P., & Pihl R. O. (2002). Oral methylphenidate-alcohol co-abuse. Journal of clinical psychopharmacology, 22(6), 633-634.

Gross S. R., Barrett S. P., Shestowsky J. S., & Pihl R. O. (2002). Ecstasy and drug consumption patterns: a Canadian rave population study. Canadian Journal of Psychiatry, 47(6), 546-51.

Barrett S. P., Archambault J., Engelberg M. J., & Pihl R. O. (2000). Hallucinogenic drugs attenuate the subjective response to alcohol in humans. Human Psychopharmacology, 15(7), 559-565.