Publications
Pub Med
PubMed comprises more than 28 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Dr. Howlett has published more than 150 peer-reviewed papers during her career. Papers from the past few years are listed below. View her full publications at:
2019
Kane AE, Howlett SE. Spelunking the biology of frailty. Mec Ageing Dev, accepted, 2019.
Heinze-Milne SD, Banga S, Howlett SE. Frailty Assessment in Animal Models. Gerontology, accepted, 2019
Rockwood K, Sanon Aigbogun M, Stanley J, Wong H, Dunn T, Chapman CAT, Howlett SE, Miguelez M, McGarrigle L, Baker RA. The Symptoms Targeted for Monitoring in a Web-Based Tracking Tool by Caregivers of People With Dementia and Agitation: Cross-Sectional Study. J Med Internet Res. 2019 Jun 28;21(6):e13360.
Kalache A, de Hoogh AI, Howlett SE, Kennedy B, Eggersdorfer M, Marsman DS, Shao A, Griffiths JC. Nutrition interventions for healthy ageing across the lifespan: a conference report. EurJ Nutr. 2019 Jun 28. doi:10.1007/s00394-019-02027-z. [Epub ahead of print].
Muscedere J, Kim P, Afilalo J, Balion C, Baracos V, Bowdish D, Cesari M, Erusalimsky JD, Fülöp T, Heckman G, Howlett SE, Khadaroo R, Kirkland JL, Macdonald M, Rodriguez Mañas L, Marzetti E, Paré G, Raina P, Rockwood K, Sierra F, Sinclair A, Skappak C, Verschoor C, Walter S. Proceeding of the Canadian Frailty Network Workshop: Identifying biomarkers of frailty to support frailty risk assessment, diagnosis and prognosis. Toronto, Monday January 15, 2018. J Frailty Aging, 8: 106-116, 2019.
Rockwood K, Howlett SE. Age-related deficit accumulation and the diseases of ageing. Mec Ageing Dev, 180:107-116, 2019.
McGarrigle L, Howlett SE, Wong H, Stanley J and Rockwood K. Characterizing the symptom of misplacing objects in people with dementia: Findings from an online tracking tool. Internat Psychogeriatrics 30:1-7, 2019.
Banga S, Heinze-Milne SD, Howlett SE. Rodent models of frailty and their application in preclinical research. Mec Ageing Dev, 179: 1-10, 2019.
Ayaz O, Banga S, Heinze-Milne S, Rose RA, Pyle WG, Howlett SE. Long term testosterone deficiency modifies myofilament and calcium handling proteins and promotes diastolic dysfunction in the aging mouse heart. Am J Physiol, 316: 768-780, 2019.
Subject of editorial Am J Physiol Heart Circ Physiol 316:H765-H767, 2019.
Blodgett J, Howlett SE, Mitnitski A, Rockwood K. Associations between a laboratory frailty index and adverse health outcomes: evidence from NHANES 2003-2006. Aging Medicine, 2:11-17, 2019.
Bisset ES, Howlett SE. The biology of frailty in humans and animals: understanding frailty and promoting translation. Aging Medicine, 2:27-34, 2019.
Kane AE, Keller K, Heinze-Milne S, Grandy SA, Howlett SE. A murine frailty index based on clinical and laboratory measurements: links between frailty and pro-inflammatory cytokines differ in a sex-specific manner. J Gerontol A Biol Sci Med Sci, 74:275-282, 2019.
Selected as Editor’s Choice.
2018
Keller K, Kane A, Heinze-Milne S, Grandy SA, Howlett SE. Chronic treatment
with the ACE inhibitor enalapril attenuates the development of frailty and
differentially modifies pro-and anti-inflammatory cytokines in aging male and female C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2018 Sep 25. doi:
10.1093/gerona/gly219. [Epub ahead of print] PubMed PMID: 30256910.
Kane AE, Shin S, Wong AA, Fertan E, Faustova N, Howlett SE, Brown RE. Sex differences in healthspan predict lifespan in the 3xTg-AD mouse model of Alzheimer’s disease. Frontiers in Aging Neuroscience, 10:172, 2018
Kane AE, Howlett SE. Differences in Cardiovascular Aging in Men and Women. Adv Exp Med Biol 1065:389-411, 2018.
Goodwin SF, Howlett SE. Daylighting sex differences in physiology. Cur Opinion Physiology, 6:iii–v, 2018.
Rockwood K, Howlett SE. Fifteen years of progress in understanding frailty and health in aging. BMC Medicine 16:220, 2018.
Bellantuono, I (and 12 signatories including Howlett, SE). Find drugs that delay many diseases of old age. Nature (Commentary). 554:293-295, 2018.
Howlett SE. Coxsackievirus B3-Induced Myocarditis: New Insights Into a Female Advantage. Can J Cardiol, 34:354-355, 2018, 2018.
2017
Feridooni HA, MacDonald JK, Ghimire A, Pyle WG, Howlett SE. Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the mouse heart. Am J Physiol, 312:H46-59, 2017.
Subject of Podcast in AJP, 2016
Selected as Editor’s Choice 2017
Gao T, Feridooni HA, Howlett SE, Pelis RM. Influence of age on intestinal bile acid transport in C57BL/6 mice. Pharmacology Research & Perspectives, 5:e00287, 2017.
Yorke A, Kane AE, Hancock Friesen CL, Howlett SE, O’Blenes, S. Development of a rat clinical frailty index. J Gerontol A Biol Sci Med Sci, 72:897-903, 2017.
Mitnitski A, Howlett SE, Rockwood K. Heterogeneity of Human Aging and Its Assessment. J Gerontol A Biol Sci Med Sci, 72:877-884, 2017.
Gordon EH, Peel NM, Samanta M, Theou O, Howlett SE, Hubbard RE. Sex differences in frailty: A systematic review and meta-analysis. Exp Gerontol, 89:30-40, 2017.
Rockwood K, Blodgett JM, Theou O, Sun MH, Feridooni HA, Mitnitski A, Rose RA, Godin J, Gregson E, Howlett SE. A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice. Sci Reports, 7:43068, 2017.
Kane AE, Huizer-Pajkos A, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Howlett SE, Hilmer SN. A comparison of two mouse frailty assessment tools. J Gerontol A Biol Sci Med Sci, 72:904-909, 2017.
Jansen HJ, Moghtadaei M, Mackasey M, Rafferty SA, Bogachev O, Sapp JL, Howlett SE, Rose RA. Atrial structure, function and arrhythmogenesis in aged and frail mice. Sci Reports, 7:44336, 2017.
Kane AE, Ayaz O, Ghimire A, Feridooni HA, Howlett SE. Implementation of the mouse frailty index. Can J Physiol Pharmacol, 95:1149-1155, 2017.
Kane AE, Gregson E, Theou O, Rockwood K, Howlett SE. The association between frailty, the metabolic syndrome and mortality over the lifespan. Geroscience 39:221-229, 2017.
Kane AE, Howlett SE. Advances in Preclinical Models of Frailty. J Gerontol A Biol Sci Med Sci, 72:867-869, 2017.
Rockwood K, Howlett SE, Hoffman D, Schindler R, Mitnitski A. Clinical meaningfulness of ADAS-Cog change in relation to goal attainment in patients on cholinesterase inhibitors. Alzheimer’s & Dementia, 13:1098-1106, 2017.
Feridooni H, Kane AE, Boroumandi A, Polidovitch N, Rose RA, Tsushima R, Howlett SE. The impact of age and frailty on ventricular structure and function in C57BL/6 mice. J Physiol (Lond), 595:3721-3742, 2017.
Parks RJ, Bogachev O, Mackasey M, Ray G, Rose RA, Howlett SE. The impact of ovariectomy on cardiac excitation-contraction coupling is mediated through cAMP/PKA-dependent mechanisms. J Mol Cell Cardiol 111:51-60, 2017.
Kane AE, Huizer-Pajkos A, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Howlett SE, Hilmer SN. A Comparison of Two Mouse Frailty Assessment Tools. J Gerontol A Biol Sci Med Sci 72:904-909, 2017.
Blodgett JM, Theou O, Howlett SE, Rockwood K. A frailty index from common clinical and laboratory tests predicts increased risk of death across the life course. Geroscience 39: 447-455, 2017.