Tamara Franklin

Education

BSc (University of King’s College)
MSc (Dalhousie University)
PhD (Swiss Federal Institute of Technology (ETHZ))

Research Interests

I would like to understand the brain functions required to engage in normal peer-to-peer social interactions. For this, my laboratory uses a combination of epigenetic and neuroconnectivity approaches to (1) identify neural circuits required for appropriate social engagement, and (2) understand how epigenetic regulation affects functional connectivity within these circuits. Our research is relevant for social-related disorders like autism spectrum disorder and social anxiety disorder.

Selected Publications

• Spiteri R, Hartley MR, Yang JR, Franklin TB (2023). Differential expression of Hdac2 in male and female mice of differing social status. Physiology and Behavior. 273, 114406. doi: 10.1016/j.physbeh.2023.114406
• Kosel F, Hartley MR, Franklin TB (2023). Aberrant cortical activity in 5xFAD mice in response to social and non-social olfactory stimuli. Journal of Alzheimer’s Disease. 97(2), 659-77. doi: 10.3233/JAD-230858
  
• Torres Muñoz P, Franklin TB (2022). The anxiogenic effects of adolescent psychological stress in male and female mice. Behavioural Brain Research.  432, 113963. https://doi.org/10.1016/j.bbr.2022.113963
  
• Kosel F, Hamilton J, Harrison S, Godin V, Franklin TB (2021). Reduced social investigation and increased injurious behaviour in transgenic 5xFAD mice. Journal of Neuroscience Research. 99, 209-22. doi:10.1002/jnr.24578. Associated Published Dataset: “5xFAD mice in their home-cage, the three-chamber sociability test and free social interaction task” https://dx.doi.org/10.20383/101.0171
• Kosel, F, Pelley, JMS, Franklin, TB (2020). Behavioural and psychological symptoms of dementia in mouse models of Alzheimer’s disease. Neuroscience and Biobehavioral Reviews 112: 634-47. doi: 10.1016/j.neubiorev.2020.02.012.
• Wheeler RV, Franklin TB (2019). The importance of the epigenome for social-related neural circuits. Epigenomics. 11, 1557-1560. doi: 10.2217/epi-2019-0255.
• Kosel F, Torres Munoz P, Yang JR, Wong AA, Franklin, TB (2019). Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer's disease. Behavioural Brain Research. 362, 160-72. Doi: 10.1016/j.bbr.2019.01.029.  Associated Published Dataset: "Social behaviours in the 5xFAD mouse" https://dx.doi.org/10.20383/101.0126.
• Franklin TB, Silva BA, Perova Z, Marrone L, Masferrer ME, Zhan Y, Kaplan A, Greetham L, Verrechia V, Halman A, Pagella S, Vyssotski AL, Illarionova A, Grinevich V, Branco T, Gross CT (2017). Prefrontal cortical control of a brainstem social behavior circuit. Nature Neuroscience. 20, 260-70.  Doi: 10.1038/nn.4470. 

Teaching

NESC/PSYO 3161 Measuring Behaviour
NESC 4007 Contemporary Issues in Neuroscience